DNA Methylation Heterogeneity Patterns in Breast Cancer Cell Lines

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dc.contributor.authorTian, Sunny
dc.contributor.authorBertelsmann, Karina
dc.contributor.authorYu, Linda
dc.contributor.authorSun, Shuying
dc.date.accessioned2020-04-16T16:45:10Z
dc.date.available2020-04-16T16:45:10Z
dc.date.issued2016-08
dc.description.abstractHeterogeneous DNA methylation patterns are linked to tumor growth. In order to study DNA methylation heterogeneity patterns for breast cancer cell lines, we comparatively study four metrics: variance, I (2) statistic, entropy, and methylation state. Using the categorical metric methylation state, we select the two most heterogeneous states to identify genes that directly affect tumor suppressor genes and high- or moderate-risk breast cancer genes. Utilizing the Gene Set Enrichment Analysis software and the ConsensusPath Database visualization tool, we generate integrated gene networks to study biological relations of heterogeneous genes. This analysis has allowed us to contribute 19 potential breast cancer biomarker genes to cancer databases by locating "hub genes" - heterogeneous genes of significant biological interactions, selected from numerous cancer modules. We have discovered a considerable relationship between these hub genes and heterogeneously methylated oncogenes. Our results have many implications for further heterogeneity analyses of methylation patterns and early detection of breast cancer susceptibility.
dc.description.departmentMathematics
dc.formatText
dc.format.extent9 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationTian, S., Bertelsmann, K., Yu, L., & Sun, S. (2016). DNA methylation heterogeneity patterns in breast cancer cell lines. Cancer Informatics, 15(S4), pp. 1–9.
dc.identifier.doihttps://doi.org/10.4137/CIN.S40300
dc.identifier.issn1176-9351
dc.identifier.urihttps://hdl.handle.net/10877/9622
dc.language.isoen
dc.publisherLibertas Academica
dc.rights.holder© The Authors.
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License.
dc.sourceCancer Informatics, 2016, Vol. 15, Issue S4, pp. 1–9.
dc.subjectheterogeneity
dc.subjecthub genes
dc.subjectDNA methylation
dc.subjectMathematics
dc.titleDNA Methylation Heterogeneity Patterns in Breast Cancer Cell Lines
dc.typeArticle

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