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dc.contributor.authorBoswell, Mikki
dc.contributor.authorLu, Yuan
dc.contributor.authorSavage, Markita G.
dc.contributor.authorHildreth, Kim
dc.contributor.authorSalinas, Raquel
dc.contributor.authorWalter, Christi A.
dc.contributor.authorWalter, Ronald B.
dc.date.accessioned2019-07-30T17:50:28Z
dc.date.available2019-07-30T17:50:28Z
dc.date.issued2019
dc.identifier.citationBoswell, M., Lu, Y., Boswell, W., Savage, M., Hildreth, K., Salinas, R., Walter, C. A., & Walter, R. B. (2019). Fluorescent Light Incites a Conserved Immune and Inflammatory Genetic Response within Vertebrate Organs (Danio rerio, Oryzias latipes and Mus musculus). Genes, 10(4), 271.en_US
dc.identifier.issn2073-4425
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/8421
dc.description.abstractFluorescent light (FL) has been utilized for ≈60 years and has become a common artificial light source under which animals, including humans, spend increasing amounts of time. Although the solar spectrum is quite dissimilar in both wavelengths and intensities, the genetic consequences of FL exposure have not been investigated. Herein, we present comparative RNA-Seq results that establish expression patterns within skin, brain, and liver for Danio rerio, Oryzias latipes, and the hairless mouse (Mus musculus) after exposure to FL. These animals represent diurnal and nocturnal lifestyles, and ≈450 million years of evolutionary divergence. In all three organisms, FL induced transcriptional changes of the acute phase response signaling pathway and modulated inflammation and innate immune responses. Our pathway and gene clustering analyses suggest cellular perception of oxidative stress is promoting induction of primary up-stream regulators IL1B and TNF. The skin and brain of the three animals as well as the liver of both fish models all exhibit increased inflammation and immune responses; however, the mouse liver suppressed the same pathways. Overall, the conserved nature of the genetic responses observed after FL exposure, among fishes and a mammal, suggest the presence of light responsive genetic circuitry deeply embedded in the vertebrate genome.en_US
dc.formatText
dc.format.extent25 pages
dc.format.medium1 file (.pdf)
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.sourceGenes, 2019, Vol. 10, No. 4, 271
dc.subjectGene expressionen_US
dc.subjectRNA-Seq
dc.subjectFluorescent light
dc.subjectAcute phase
dc.subjectOxidative stress
dc.titleFluorescent Light Incites a Conserved Immune and Inflammatory Genetic Response within Vertebrate Organs (Danio rerio, Oryzias latipes and Mus musculus)en_US
txstate.documenttypeArticle
dc.identifier.doihttps://doi.org/10.3390/genes10040271
txstate.departmentChemistry and Biochemistry


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