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dc.contributor.authorGovindaraju, Karthik ( )
dc.contributor.authorIngels, Aude ( )
dc.contributor.authorHasan, Md Nabiul ( )
dc.contributor.authorSun, Dandan ( )
dc.contributor.authorMathieu, Veronique ( )
dc.contributor.authorMasi, Marco ( Orcid Icon 0000-0003-0609-8902 )
dc.contributor.authorEvidente, Antonio ( )
dc.contributor.authorKornienko, Alexander ( )
dc.date.accessioned2019-08-28T18:27:46Z
dc.date.available2019-08-28T18:27:46Z
dc.date.issued2018-02
dc.identifier.citationGovindaraju, K., Ingels, A., Hasan, M. N., Sun, D., Mathieu, V., Masi, M., Evidente, A., & Kornienko, A. (2018). Synthetic analogues of the montanine-type alkaloids with activity against apoptosis-resistant cancer cells. Bioorganic and Medicinal Chemistry Letters, 28(4), pp. 589–593.en_US
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/8559
dc.description.abstractIn a search of small molecules active against apoptosis-resistant cancer cells, a skeletal rearrangement of alkaloid haemanthamine was utilized to generate a series of compounds possessing the alkaloid montanine ring system. The synthesized compounds were found to inhibit proliferation of cancer cells resistant to apoptosis at micromolar concentrations. Selected compounds were also active against patient-derived glioblastoma cells expressing stem-cell markers. This is the first report describing the preparation of synthetic analogues of the montanine-type alkaloids with antiproliferative activity. The compounds prepared in the current investigation appear to be a useful starting point for the development of agents to fight cancers with apoptosis resistance, and thus, associated with poor prognoses.en_US
dc.formatText
dc.format.extent13 pages
dc.format.medium1 file (.pdf)
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.sourceBioorganic and Medicinal Chemistry Letters, 2018, Vol. 28, No. 4, pp. 589–593
dc.subjectAntiproliferative activityen_US
dc.subjectApoptosis resistance
dc.subjectMontanine
dc.subjectHaemanthamine
dc.subjectManthine
dc.titleSynthetic Analogues of the Montanine-type Alkaloids with Activity Against Apoptosis-resistant Cancer Cellsen_US
txstate.documenttypeArticle
dc.identifier.doihttps://doi.org/10.1016/j.bmcl.2018.01.041
txstate.departmentChemistry and Biochemistry


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