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dc.contributor.authorGovindaraju, Karthik ( )
dc.contributor.authorMasi, Marco ( Orcid Icon 0000-0003-0609-8902 )
dc.contributor.authorColin, Margaux ( )
dc.contributor.authorMathieu, Veronique ( )
dc.contributor.authorEvidente, Antonio ( )
dc.contributor.authorHudnall, Todd W. ( Orcid Icon 0000-0002-9260-2986 )
dc.contributor.authorKornienko, Alexander ( )
dc.date.accessioned2019-08-30T13:56:37Z
dc.date.available2019-08-30T13:56:37Z
dc.date.issued2018-01
dc.identifier.citationGovindaraju, K., Masi, M., Colin, M., Mathieu, V., Evidente, A., Hudnall, T. W., & Kornienko, A. (2018). Novel topologically complex scaffold derived from alkaloid haemanthamine. Molecules, 23(2).en_US
dc.identifier.urihttps://digital.library.txstate.edu/handle/10877/8573
dc.description.abstractThe generation of natural product-like compound collections has become an important area of research due to low hit rates found with synthetic high-throughput libraries. One method of generating compounds occupying the areas of chemical space not accessible to synthetic planar heterocyclic structures is the utilization of natural products as starting materials. In the current work, using a ring-closing iodoalkoxylation reaction, alkaloid haemanthamine was transformed into a unique structural framework possessing an intricate ring system and a large number of stereocenters. The structure of the new compound was confirmed with an X-ray analysis. A small number of derivatives of this new compound were synthesized as a demonstration of the possibility of generating a large natural product-like compound collection based on the new structural framework.en_US
dc.formatText
dc.format.extent8 pages
dc.format.medium1 file (.pdf)
dc.language.isoen_USen_US
dc.publisherMultidisciplinary Digital Publishing Instituteen_US
dc.sourceMolecules, 2018, Vol. 23, No. 2
dc.subjectNatural product-likeen_US
dc.subjectDiversity-oriented synthesis
dc.subjectHaemanthamine
dc.subjectHaemanthidine
dc.subjectIodoalkoxylation
dc.subjectBiological activity
dc.titleNovel Topologically Complex Scaffold Derived from Alkaloid Haemanthamineen_US
txstate.documenttypeArticle
dc.identifier.doihttps://doi.org/10.3390/molecules23020255
txstate.departmentChemistry and Biochemistry


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