Underexpression of Specific Interferon Genes Is Associated with Poor Prognosis of Melanoma

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dc.contributor.authorZainulabadeen, Aamir
dc.contributor.authorYao, Philip
dc.contributor.authorZare, Habil
dc.date.accessioned2019-04-05T16:16:17Z
dc.date.available2019-04-05T16:16:17Z
dc.date.issued2017-01-23
dc.description.abstractBecause the prognosis of melanoma is challenging and inaccurate when using current clinical approaches, clinicians are seeking more accurate molecular markers to improve risk models. Accordingly, we performed a survival analysis on 404 samples from The Cancer Genome Atlas (TCGA) cohort of skin cutaneous melanoma. Using our recently developed gene network model, we identified biological signatures that confidently predict the prognosis of melanoma (p-value < 10−5). Our model predicted 38 cases as low–risk and 54 cases as high–risk. The probability of surviving at least 5 years was 64% for low–risk and 14% for high–risk cases. In particular, we found that the overexpression of specific genes in the mitotic cell cycle pathway and the underexpression of specific genes in the interferon pathway are both associated with poor prognosis. We show that our predictive model assesses the risk more accurately than the traditional Clark staging method. Therefore, our model can help clinicians design treatment strategies more effectively. Furthermore, our findings shed light on the biology of melanoma and its prognosis. This is the first in vivo study that demonstrates the association between the interferon pathway and the prognosis of melanoma.
dc.description.departmentComputer Science
dc.formatText
dc.format.extent15 pages
dc.format.medium1 file (.pdf)
dc.identifier.citationZainulabadeen, A., Yao, P. & Zare, H. (2017). Underexpression of Specific Interferon Genes Is Associated with Poor Prognosis of Melanoma. PLoS One, 12(1): e0170025.
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0170025
dc.identifier.urihttps://hdl.handle.net/10877/7961
dc.language.isoen
dc.publisherPublic Library of Science
dc.rights.licenseThis work is licensed under a Creative Commons Attribution 4.0 International License.
dc.sourcePLoS One, 2017, Vol. 12, No. 1 : e0170025.
dc.subjectmelanoma
dc.subjectprognosis
dc.subjectinterferon genes
dc.subjectinterferon pathway
dc.subjectComputer Science
dc.titleUnderexpression of Specific Interferon Genes Is Associated with Poor Prognosis of Melanoma
dc.typeArticle

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